mia-2dseriesgradMAD(1)


NAME

   mia-2dseriesgradMAD  -  Evaluate  the  time-intensity gradient MAD in a
   series of images.

SYNOPSIS

   mia-2dseriesgradMAD    -i    <in-file>    -o    <out-file>    [options]
   <PLUGINS:2dimage/filter>

DESCRIPTION

   mia-2dseriesgradMAD  Given  a  set  of  images  of  temporal sucession,
   evaluates the pixel-wise temporal gradient and then its median  average
   distance (MAD) and stores the result in an image. Spacial pre-filtering
   may be applied as given additional plugin(s) (filter/2dimage).

OPTIONS

          -i --in-file=(input, required); string
                 input segmentation set

          -o --out-file=(output, required); io
                 output  file  name   For   supported   file   types   see
                 PLUGINS:2dimage/io

          -k --skip=0
                 Skip files at the beginningSkip files at the beginning

          -e --enlarge-boundary=5
                 Enlarge  cropbox  by  number  of pixelsEnlarge cropbox by
                 number of pixels

          -c --crop
                 crop image before running statistics

   Help & Info
          -V --verbose=warning
                 verbosity of output, print messages of  given  level  and
                 higher   priorities.  Supported  priorities  starting  at
                 lowest level are:
                    info  Low level messages
                    trace  Function call trace
                    fail  Report test failures
                    warning  Warnings
                    error  Report errors
                    debug  Debug output
                    message  Normal messages
                    fatal  Report only fatal errors

             --copyright
                 print copyright information

          -h --help
                 print this help

          -? --usage
                 print a short help

             --version
                 print the version number and exit

   Processing
             --threads=-1
                 Maxiumum number of threads  to  use  for  processing,This
                 number  should be lower or equal to the number of logical
                 processor  cores   in   the   machine.   (-1:   automatic
                 estimation).Maxiumum   number   of  threads  to  use  for
                 processing,This number should be lower or  equal  to  the
                 number  of  logical  processor cores in the machine. (-1:
                 automatic estimation).

PLUGINS: 1d/spacialkernel

   cdiff     Central difference filter kernel, mirror boundary  conditions
             are used.

                 (no parameters)

   gauss     spacial Gauss filter kernel, supported parameters are:

                 w = 1; uint in [0, inf)
                   half filter width.

   scharr    This  plugin  provides  the  1D folding kernel for the Scharr
             gradient filter

                 (no parameters)

PLUGINS: 1d/splinekernel

   bspline   B-spline kernel creation , supported parameters are:

                 d = 3; int in [0, 5]
                   Spline degree.

   omoms     OMoms-spline kernel creation, supported parameters are:

                 d = 3; int in [3, 3]
                   Spline degree.

PLUGINS: 2dimage/combiner

   absdiff   Image combiner 'absdiff'

                 (no parameters)

   add       Image combiner 'add'

                 (no parameters)

   div       Image combiner 'div'

                 (no parameters)

   mul       Image combiner 'mul'

                 (no parameters)

   sub       Image combiner 'sub'

                 (no parameters)

PLUGINS: 2dimage/filter

   adaptmed  2D image adaptive median filter, supported parameters are:

                 w = 2; int in [1, inf)
                   half filter width.

   admean    An adaptive mean filter that works like a normal mean filter,
             if  the  intensity  variation within the filter mask is lower
             then the intensity variation in the  whole  image,  that  the
             uses  a special formula if the local variation is higher then
             the image intensity variation., supported parameters are:

                 w = 1; int in [1, inf)
                   half filter width.

   aniso     2D Anisotropic image filter, supported parameters are:

                 epsilon = 1; float in (0, inf)
                   iteration change threshold.

                 iter = 100; int in [1, 10000]
                   number of iterations.

                 k = -1; float in [0, 100]
                   k the noise threshold (<=0 -> adaptive).

                 n = 8; set
                   neighbourhood.  Supported values are:( 4,  8,  )

                 psi = tuckey; dict
                   edge stopping function.  Supported values are:
                       guess  test stopping function
                       tuckey  tukey stopping function
                       pm1  stopping function 1
                       pm2  stopping function 2

   bandpass  intensity bandpass filter, supported parameters are:

                 max = 3.40282e+38; float
                   maximum of the band.

                 min = 0; float
                   minimum of the band.

   binarize  image binarize filter, supported parameters are:

                 max = 3.40282e+38; float
                   maximum of accepted range.

                 min = 0; float
                   minimum of accepted range.

   close     morphological close, supported parameters are:

                 hint = black; set
                   a hint at the main  image  content.   Supported  values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring   element.    For  supported  plug-ins  see
                   PLUGINS:2dimage/shape

   combiner  Combine two images  with  the  given  combiner  operator.  if
             'reverse'  is  set  to false, the first operator is the image
             passed through the filter pipeline, and the second  image  is
             loaded  from  the  file  given with the 'image' parameter the
             moment the filter is run., supported parameters are:

                 image =(input, required, string)
                   second image that is needed in the combiner.

                 op =(required, factory)
                   Image combiner  to  be  applied  to  the  images.   For
                   supported plug-ins see PLUGINS:2dimage/combiner

                 reverse = 0; bool
                   reverse  the  order  in  which the images passed to the
                   combiner.

   convert   image pixel format conversion  filter,  supported  parameters
             are:

                 a = 1; float
                   linear conversion parameter a.

                 b = 0; float
                   linear conversion parameter b.

                 map = opt; dict
                   conversion mapping.  Supported values are:
                       opt    apply a linear transformation that maps the
                       real input range to the full output range
                       range  apply linear transformation that  maps  the
                       input data type range to the output data type range
                       copy  copy data when converting
                       linear  apply linear transformation x -> a*x+b
                       optstat   apply a linear transform that maps based
                       on input mean and  variation  to  the  full  output
                       range

                 repn = ubyte; dict
                   output pixel type.  Supported values are:
                       none  no pixel type defined
                       float  floating point 32 bit
                       sbyte  signed 8 bit
                       ulong  unsigned 64 bit
                       double  floating point 64 bit
                       sint  signed 32 bit
                       ushort  unsigned 16 bit
                       sshort  signed 16 bit
                       uint  unsigned 32 bit
                       slong  signed 64 bit
                       bit  binary data
                       ubyte  unsigned 8 bit

   crop      Crop  a  region  of an image, the region is always clamped to
             the original image size., supported parameters are:

                 end = [[-1,-1]]; streamable
                   end of crop region.

                 start = [[0,0]]; streamable
                   start of crop region.

   dilate    2d image stack dilate filter, supported parameters are:

                 hint = black; set
                   a hint at the main  image  content.   Supported  values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring   element.    For  supported  plug-ins  see
                   PLUGINS:2dimage/shape

   distance  2D image distance filter, evaluates the distance  map  for  a
             binary mask.

                 (no parameters)

   downscale Downscale  the  input  image  by  using a given block size to
             define the downscale factor. Prior to scaling  the  image  is
             filtered  by  a  smoothing filter to eliminate high frequency
             data and avoid aliasing artifacts., supported parameters are:

                 b = [[1,1]]; 2dbounds
                   blocksize.

                 bx = 1; uint in [1, inf)
                   blocksize in x direction.

                 by = 1; uint in [1, inf)
                   blocksize in y direction.

                 kernel = gauss; string
                   smoothing filter kernel to be applied, the size of  the
                   filter is estimated based on the blocksize..

   erode     2d image stack erode filter, supported parameters are:

                 hint = black; set
                   a  hint  at  the  main image content.  Supported values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring  element.   For  supported   plug-ins   see
                   PLUGINS:2dimage/shape

   gauss     isotropic 2D gauss filter, supported parameters are:

                 w = 1; int in [0, inf)
                   filter width parameter.

   gradnorm  2D image to gradient norm filter, supported parameters are:

                 normalize = 0; bool
                   Normalize the gradient norms to range [0,1]..

   invert    intensity invert filter

                 (no parameters)

   kmeans    2D  image k-means filter. In the output image the pixel value
             represents the class membership and  the  class  centers  are
             stored as attribute in the image., supported parameters are:

                 c = 3; int in [2, inf)
                   number of classes.

   label     Label  connected  components in a binary 2D image., supported
             parameters are:

                 n = 4n; factory
                   Neighborhood  mask  to  describe  connectivity..    For
                   supported plug-ins see PLUGINS:2dimage/shape

   labelmap  Image  filter  to remap label id's. Only applicable to images
             with integer valued intensities/labels., supported parameters
             are:

                 map =(input, required, string)
                   Label mapping file.

   labelscale
             A  filter  that  only  creates output voxels that are already
             created in the input image. Scaling is done by using a voting
             algorithms  that  selects the target pixel value based on the
             highest pixel count of a certain label in  the  corresponding
             source  region.  If  the region comprises two labels with the
             same count, the one with the lower  number  wins.,  supported
             parameters are:

                 out-size =(required, 2dbounds)
                   target size given as two coma separated values.

   load      Load  the  input  image from a file and use it to replace the
             current image in the pipeline., supported parameters are:

                 file =(input, required, string)
                   name of the input file to load from..

   mask      2D masking, one of the two input images must by of type bit.,
             supported parameters are:

                 fill = min; dict
                   fill  style  for pixels outside of the mask.  Supported
                   values are:
                       max  set values outside the mask  to  the  maximum
                       value found in the image..
                       zero  set the values outside the mask to zero.
                       min    set  values outside the mask to the minimum
                       value found in the image.

                 input =(input, required, string)
                   second input image file name.

                 inverse = 0; bool
                   set to true to use the inverse of the mask for masking.

   maxflow   This  filter  implements  the  uses  the   max-flow   min-cut
             algorithmfor image segmentation, supported parameters are:

                 sink-flow =(input, required, string)
                   Image of float type to define the per-pixel flow to the
                   sink.

                 source-flow =(input, required, string)
                   Image of float type to define the per-pixel flow to the
                   source.

   mean      2D image mean filter, supported parameters are:

                 w = 1; int in [1, inf)
                   half filter width.

   meanvar   Filter  that evaluates simultaniously the pixel wise mean and
             the variance of an image in a given window. Pixel intensities
             below  the  given  threshold  will  be  ignored  and at their
             loctions the output mean and variation are set to  zero.  The
             mean intensity image is directly passed as float image to the
             pipeline, the variation image is saved to a file  given  with
             the varfile parameter., supported parameters are:

                 thresh = 0; double in [0, inf)
                   Intensity    thresholding    parameter:   Pixels   with
                   intensities below this threshold will be set  to  zero,
                   and also not used when evaluating mean and variation.

                 varfile =(output, required, string)
                   name  of  the  output  file to save the variation image
                   too..

                 w = 1; uint in [1, inf)
                   filter width parameter.

   median    2D image median filter, supported parameters are:

                 w = 1; int in [1, inf)
                   half filter width.

   medianmad Filter that evaluates simultaniously the  pixel  wise  median
             and  the  median  absolute  deviation  (MAD) of an image in a
             given window. Pixel intensities  below  the  given  threshold
             will  be  ignored and at their loctions the output median and
             MAD are set to zero. The median intensity image  is  directly
             passed  to  the  pipeline,  the variation image is saved to a
             file given with the varfile  parameter.  Both  output  images
             have  the  same  pixel  type like the input image., supported
             parameters are:

                 madfile =(output, required, string)
                   name of the output file to  save  the  median  absolute
                   deviation image too..

                 thresh = 0; double in [0, inf)
                   Intensity    thresholding    parameter:   Pixels   with
                   intensities below this threshold will be set  to  zero,
                   and also not used when evaluating mean and variation.

                 w = 1; uint in [1, inf)
                   filter width parameter.

   mlv       Mean  of Least Variance 2D image filter, supported parameters
             are:

                 w = 1; int in [1, inf)
                   filter width parameter.

   ngfnorm   2D image to normalized-gradiend-field-norm filter

                 (no parameters)

   noise     2D image noise filter: add additive or modulated noise to  an
             image, supported parameters are:

                 g = [gauss:mu=0,sigma=10]; factory
                   noise    generator.    For   supported   plug-ins   see
                   PLUGINS:generator/noise

                 mod = 0; bool
                   additive or modulated noise.

   open      morphological open, supported parameters are:

                 hint = black; set
                   a hint at the main  image  content.   Supported  values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring   element.    For  supported  plug-ins  see
                   PLUGINS:2dimage/shape

   pruning   Morphological pruning. Pruning until convergence  will  erase
             all pixels but closed loops., supported parameters are:

                 iter = 0; int in [1, 1000000]
                   Number of iterations to run, 0=until convergence.

   regiongrow
             Region   growing   startin  from  a  seed  until  only  along
             increasing gradients, supported parameters are:

                 n = 8n; factory
                   Neighborhood  shape.   For   supported   plug-ins   see
                   PLUGINS:2dimage/shape

                 seed =(input, required, string)
                   seed image (bit valued).

   sandp     salt and pepper  3d filter, supported parameters are:

                 thresh = 100; float in (0, inf)
                   thresh value.

                 w = 1; int in [1, inf)
                   filter width parameter.

   scale     2D image downscale filter, supported parameters are:

                 interp = [bspline:d=3]; factory
                   interpolation  method to be used .  For supported plug-
                   ins see PLUGINS:1d/splinekernel

                 s = [[0,0]]; 2dbounds
                   target size as 2D vector.

                 sx = 0; uint in [0, inf)
                   target size in x direction, 0: use input size.

                 sy = 0; uint in [0, inf)
                   target size in y direction, 0: use input size.

   selectbig 2D label select biggest component filter

                 (no parameters)

   sepconv   2D image intensity separaple  convolution  filter,  supported
             parameters are:

                 kx = [gauss:w=1]; factory
                   filter  kernel  in x-direction.  For supported plug-ins
                   see PLUGINS:1d/spacialkernel

                 ky = [gauss:w=1]; factory
                   filter kernel in y-direction.  For  supported  plug-ins
                   see PLUGINS:1d/spacialkernel

   shmean    2D  image  filter  that  evaluates  the  mean  over  a  given
             neighborhood shape, supported parameters are:

                 shape = 8n; factory
                   neighborhood shape to evaluate the mean.  For supported
                   plug-ins see PLUGINS:2dimage/shape

   sobel     The  2D  Sobel  filter for gradient evaluation. Note that the
             output pixel type of the filtered image is the  same  as  the
             input  pixel  type,  so  converting the input beforehand to a
             floating point  valued  image  is  recommendable.,  supported
             parameters are:

                 dir = x; dict
                   Gradient direction.  Supported values are:
                       y  gradient in y-direction
                       x  gradient in x-direction

   sort-label
             This  plug-in  sorts the labels of a gray-scale image so that
             the lowest label value corresponts to the lable with  themost
             pixels. The background (0) is not touched

                 (no parameters)

   sws       seeded  watershead.  The  algorithm  extracts exactly so many
             reagions as initial labels are  given  in  the  seed  image.,
             supported parameters are:

                 grad = 0; bool
                   Interpret the input image as gradient. .

                 mark = 0; bool
                   Mark the segmented watersheds with a special gray scale
                   value.

                 n = [sphere:r=1]; factory
                   Neighborhood  for  watershead  region   growing.    For
                   supported plug-ins see PLUGINS:2dimage/shape

                 seed =(input, required, string)
                   seed  input image containing the lables for the initial
                   regions.

   tee       Save the input image to a file and also pass  it  through  to
             the next filter, supported parameters are:

                 file =(output, required, string)
                   name of the output file to save the image too..

   thinning  Morphological   thinning.  Thinning  until  convergence  will
             result in a 8-connected skeleton, supported parameters are:

                 iter = 0; int in [1, 1000000]
                   Number of iterations to run, 0=until convergence.

   thresh    This filter sets all pixels of an image  to  zero  that  fall
             below  a  certain  threshold  and whose neighbours in a given
             neighborhood  shape  also  fall  below  a   this   threshold,
             supported parameters are:

                 shape = 4n; factory
                   neighborhood shape to take into account.  For supported
                   plug-ins see PLUGINS:2dimage/shape

                 thresh = 5; double
                   The threshold value.

   tmean     2D image thresholded tmean filter: The output pixel value  is
             zero  if  the input pixel value is below the given threshold,
             otherwise the pixels  in  the  evaluation  windows  are  only
             considered   if  the  input  pixel  intensity  is  above  the
             threshold., supported parameters are:

                 t = 0; float
                   Threshold for pixels not to take into account.

                 w = 1; int in [1, inf)
                   half filter width.

   transform Transform the input image  with  the  given  transformation.,
             supported parameters are:

                 file =(input, required, string)
                   Name of the file containing the transformation..

   ws        basic watershead segmentation., supported parameters are:

                 evalgrad = 0; bool
                   Set  to  1  if  the  input  image  does not represent a
                   gradient norm image.

                 mark = 0; bool
                   Mark the segmented watersheds with a special gray scale
                   value.

                 n = [sphere:r=1]; factory
                   Neighborhood   for   watershead  region  growing.   For
                   supported plug-ins see PLUGINS:2dimage/shape

                 thresh = 0; float in [0, 1)
                   Relative gradient  norm  threshold.  The  actual  value
                   threshold  value  is  thresh  * (max_grad - min_grad) +
                   min_grad. Bassins separated by gradients with  a  lower
                   norm will be joined.

PLUGINS: 2dimage/io

   bmp       BMP  2D-image  input/output  support.  The  plug-in  supports
             reading and writing of binary images  and  8-bit  gray  scale
             images.  read-only  support  is provided for 4-bit gray scale
             images. The color table is ignored and the pixel  values  are
             taken as literal gray scale values.

                 Recognized file extensions:  .BMP, .bmp

                 Supported element types:
                   binary data, unsigned 8 bit

   datapool  Virtual IO to and from the internal data pool

                 Recognized file extensions:  .@

   dicom     2D image io for DICOM

                 Recognized file extensions:  .DCM, .dcm

                 Supported element types:
                   signed 16 bit, unsigned 16 bit

   exr       a 2dimage io plugin for OpenEXR images

                 Recognized file extensions:  .EXR, .exr

                 Supported element types:
                   unsigned 32 bit, floating point 32 bit

   jpg       a 2dimage io plugin for jpeg gray scale images

                 Recognized file extensions:  .JPEG, .JPG, .jpeg, .jpg

                 Supported element types:
                   unsigned 8 bit

   png       a 2dimage io plugin for png images

                 Recognized file extensions:  .PNG, .png

                 Supported element types:
                   binary data, unsigned 8 bit, unsigned 16 bit

   raw       RAW 2D-image output support

                 Recognized file extensions:  .RAW, .raw

                 Supported element types:
                   binary  data,  signed  8 bit, unsigned 8 bit, signed 16
                   bit, unsigned 16 bit, signed 32 bit, unsigned  32  bit,
                   floating point 32 bit, floating point 64 bit

   tif       TIFF 2D-image input/output support

                 Recognized file extensions:  .TIF, .TIFF, .tif, .tiff

                 Supported element types:
                   binary  data, unsigned 8 bit, unsigned 16 bit, unsigned
                   32 bit

   vista     a 2dimage io plugin for vista images

                 Recognized file extensions:  .-, .V, .VISTA, .v, .vista

                 Supported element types:
                   binary data, signed 8 bit, unsigned 8  bit,  signed  16
                   bit,  unsigned  16 bit, signed 32 bit, unsigned 32 bit,
                   floating point 32 bit, floating point 64 bit

PLUGINS: 2dimage/shape

   1n        A shape that only contains the central point

                 (no parameters)

   4n        4n neighborhood 2D shape

                 (no parameters)

   8n        8n neighborhood 2D shape

                 (no parameters)

   rectangle rectangle shape mask creator, supported parameters are:

                 fill = 1; bool
                   create a filled shape.

                 height = 2; int in [1, inf)
                   height of rectangle.

                 width = 2; int in [1, inf)
                   width of rectangle.

   sphere    Closed spherical neighborhood shape of radius  r.,  supported
             parameters are:

                 r = 2; float in (0, inf)
                   sphere radius.

   square    square shape mask creator, supported parameters are:

                 fill = 1; bool
                   create a filled shape.

                 width = 2; int in [1, inf)
                   width of rectangle.

PLUGINS: 2dtransform/io

   bbs       Binary (non-portable) serialized IO of 2D transformations

                 Recognized file extensions:  .bbs

   datapool  Virtual IO to and from the internal data pool

                 Recognized file extensions:  .@

   vista     Vista storage of 2D transformations

                 Recognized file extensions:  .v2dt

   xml       XML serialized IO of 2D transformations

                 Recognized file extensions:  .x2dt

PLUGINS: generator/noise

   gauss     This   noise   generator   creates  random  values  that  are
             distributed according to a Gaussien distribution by using the
             Box-Muller transformation., supported parameters are:

                 mu = 0; float
                   mean of distribution.

                 seed = 0; uint in [0, inf)
                   set random seed (0=init based on system time).

                 sigma = 1; float in (0, inf)
                   standard derivation of distribution.

   uniform   Uniform  noise  generator  using  C  stdlib rand(), supported
             parameters are:

                 a = 0; float
                   lower bound if noise range.

                 b = 1; float
                   higher bound if noise range.

                 seed = 0; uint in [0, inf)
                   set random seed (0=init based on system time).

EXAMPLE

   Evaluate the MAD-image of the bounding box surrounding the segmentation
   from  a  series  segment.set. No spacial filtering will be applied. The
   bounding box will be enlarged by 3 pixels in all directions. Store  the
   image in OpenEXR format.

   mia-2dseriesgradMAD  -i segment.set -o mad.exr -c -e 3

AUTHOR(s)

   Gert Wollny

COPYRIGHT

   This  software  is Copyright (c) 19992015 Leipzig, Germany and Madrid,
   Spain.   It  comes   with   ABSOLUTELY   NO  WARRANTY   and   you   may
   redistribute  it  under  the  terms  of  the GNU GENERAL PUBLIC LICENSE
   Version 3 (or later). For more information run  the  program  with  the
   option '--copyright'.





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