mia-2dseriessmoothgradMAD(1)


NAME

   mia-2dseriessmoothgradMAD - Evaluate pixel-wise time-intensity gradient
   of a 2D image series.

SYNOPSIS

   mia-2dseriessmoothgradMAD  -i   <in-file>   -o   <out-file>   [options]
   <PLUGINS:2dimage/filter>

DESCRIPTION

   mia-2dseriessmoothgradMAD  Given a set of images of temporal sucession,
   evaluate the temporal pixel-wise gaussian and evaluate  pixel-wise  its
   MAD.A  spacial  pre-filtering  may  be applied by specifying additional
   plugins (filter/2dimage)

OPTIONS

          -i --in-file=(input, required); string
                 input segmentation set

          -o --out-file=(output, required); io
                 output  file  name   For   supported   file   types   see
                 PLUGINS:2dimage/io

          -k --skip=0
                 Skip files at the beginningSkip files at the beginning

          -e --enlarge-boundary=5
                 Enlarge  cropbox  by  number  of pixelsEnlarge cropbox by
                 number of pixels

          -c --crop
                 crop image before running statistics

          -g --gauss=1
                 gauss filter width for moothing the gradientgauss  filter
                 width for moothing the gradient

   Help & Info
          -V --verbose=warning
                 verbosity  of  output,  print messages of given level and
                 higher  priorities.  Supported  priorities  starting   at
                 lowest level are:
                    info  Low level messages
                    trace  Function call trace
                    fail  Report test failures
                    warning  Warnings
                    error  Report errors
                    debug  Debug output
                    message  Normal messages
                    fatal  Report only fatal errors

             --copyright
                 print copyright information

          -h --help
                 print this help

          -? --usage
                 print a short help

             --version
                 print the version number and exit

   Processing
             --threads=-1
                 Maxiumum  number  of  threads  to use for processing,This
                 number should be lower or equal to the number of  logical
                 processor   cores   in   the   machine.   (-1:  automatic
                 estimation).Maxiumum  number  of  threads  to   use   for
                 processing,This  number  should  be lower or equal to the
                 number of logical processor cores in  the  machine.  (-1:
                 automatic estimation).

PLUGINS: 1d/spacialkernel

   cdiff     Central  difference filter kernel, mirror boundary conditions
             are used.

                 (no parameters)

   gauss     spacial Gauss filter kernel, supported parameters are:

                 w = 1; uint in [0, inf)
                   half filter width.

   scharr    This plugin provides the 1D folding  kernel  for  the  Scharr
             gradient filter

                 (no parameters)

PLUGINS: 1d/splinekernel

   bspline   B-spline kernel creation , supported parameters are:

                 d = 3; int in [0, 5]
                   Spline degree.

   omoms     OMoms-spline kernel creation, supported parameters are:

                 d = 3; int in [3, 3]
                   Spline degree.

PLUGINS: 2dimage/combiner

   absdiff   Image combiner 'absdiff'

                 (no parameters)

   add       Image combiner 'add'

                 (no parameters)

   div       Image combiner 'div'

                 (no parameters)

   mul       Image combiner 'mul'

                 (no parameters)

   sub       Image combiner 'sub'

                 (no parameters)

PLUGINS: 2dimage/filter

   adaptmed  2D image adaptive median filter, supported parameters are:

                 w = 2; int in [1, inf)
                   half filter width.

   admean    An adaptive mean filter that works like a normal mean filter,
             if the intensity variation within the filter  mask  is  lower
             then  the  intensity  variation  in the whole image, that the
             uses a special formula if the local variation is higher  then
             the image intensity variation., supported parameters are:

                 w = 1; int in [1, inf)
                   half filter width.

   aniso     2D Anisotropic image filter, supported parameters are:

                 epsilon = 1; float in (0, inf)
                   iteration change threshold.

                 iter = 100; int in [1, 10000]
                   number of iterations.

                 k = -1; float in [0, 100]
                   k the noise threshold (<=0 -> adaptive).

                 n = 8; set
                   neighbourhood.  Supported values are:( 4,  8,  )

                 psi = tuckey; dict
                   edge stopping function.  Supported values are:
                       guess  test stopping function
                       tuckey  tukey stopping function
                       pm1  stopping function 1
                       pm2  stopping function 2

   bandpass  intensity bandpass filter, supported parameters are:

                 max = 3.40282e+38; float
                   maximum of the band.

                 min = 0; float
                   minimum of the band.

   binarize  image binarize filter, supported parameters are:

                 max = 3.40282e+38; float
                   maximum of accepted range.

                 min = 0; float
                   minimum of accepted range.

   close     morphological close, supported parameters are:

                 hint = black; set
                   a  hint  at  the  main image content.  Supported values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring  element.   For  supported   plug-ins   see
                   PLUGINS:2dimage/shape

   combiner  Combine  two  images  with  the  given  combiner operator. if
             'reverse' is set to false, the first operator  is  the  image
             passed  through  the filter pipeline, and the second image is
             loaded from the file given with  the  'image'  parameter  the
             moment the filter is run., supported parameters are:

                 image =(input, required, string)
                   second image that is needed in the combiner.

                 op =(required, factory)
                   Image  combiner  to  be  applied  to  the  images.  For
                   supported plug-ins see PLUGINS:2dimage/combiner

                 reverse = 0; bool
                   reverse the order in which the  images  passed  to  the
                   combiner.

   convert   image  pixel  format  conversion filter, supported parameters
             are:

                 a = 1; float
                   linear conversion parameter a.

                 b = 0; float
                   linear conversion parameter b.

                 map = opt; dict
                   conversion mapping.  Supported values are:
                       opt  apply a linear transformation that  maps  the
                       real input range to the full output range
                       range    apply linear transformation that maps the
                       input data type range to the output data type range
                       copy  copy data when converting
                       linear  apply linear transformation x -> a*x+b
                       optstat  apply a linear transform that maps  based
                       on  input  mean  and  variation  to the full output
                       range

                 repn = ubyte; dict
                   output pixel type.  Supported values are:
                       none  no pixel type defined
                       float  floating point 32 bit
                       sbyte  signed 8 bit
                       ulong  unsigned 64 bit
                       double  floating point 64 bit
                       sint  signed 32 bit
                       ushort  unsigned 16 bit
                       sshort  signed 16 bit
                       uint  unsigned 32 bit
                       slong  signed 64 bit
                       bit  binary data
                       ubyte  unsigned 8 bit

   crop      Crop a region of an image, the region is  always  clamped  to
             the original image size., supported parameters are:

                 end = [[-1,-1]]; streamable
                   end of crop region.

                 start = [[0,0]]; streamable
                   start of crop region.

   dilate    2d image stack dilate filter, supported parameters are:

                 hint = black; set
                   a  hint  at  the  main image content.  Supported values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring  element.   For  supported   plug-ins   see
                   PLUGINS:2dimage/shape

   distance  2D  image  distance  filter, evaluates the distance map for a
             binary mask.

                 (no parameters)

   downscale Downscale the input image by using  a  given  block  size  to
             define  the  downscale  factor. Prior to scaling the image is
             filtered by a smoothing filter to  eliminate  high  frequency
             data and avoid aliasing artifacts., supported parameters are:

                 b = [[1,1]]; 2dbounds
                   blocksize.

                 bx = 1; uint in [1, inf)
                   blocksize in x direction.

                 by = 1; uint in [1, inf)
                   blocksize in y direction.

                 kernel = gauss; string
                   smoothing  filter kernel to be applied, the size of the
                   filter is estimated based on the blocksize..

   erode     2d image stack erode filter, supported parameters are:

                 hint = black; set
                   a hint at the main  image  content.   Supported  values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring   element.    For  supported  plug-ins  see
                   PLUGINS:2dimage/shape

   gauss     isotropic 2D gauss filter, supported parameters are:

                 w = 1; int in [0, inf)
                   filter width parameter.

   gradnorm  2D image to gradient norm filter, supported parameters are:

                 normalize = 0; bool
                   Normalize the gradient norms to range [0,1]..

   invert    intensity invert filter

                 (no parameters)

   kmeans    2D image k-means filter. In the output image the pixel  value
             represents  the  class  membership  and the class centers are
             stored as attribute in the image., supported parameters are:

                 c = 3; int in [2, inf)
                   number of classes.

   label     Label connected components in a binary 2D  image.,  supported
             parameters are:

                 n = 4n; factory
                   Neighborhood   mask  to  describe  connectivity..   For
                   supported plug-ins see PLUGINS:2dimage/shape

   labelmap  Image filter to remap label id's. Only applicable  to  images
             with integer valued intensities/labels., supported parameters
             are:

                 map =(input, required, string)
                   Label mapping file.

   labelscale
             A filter that only creates output  voxels  that  are  already
             created in the input image. Scaling is done by using a voting
             algorithms that selects the target pixel value based  on  the
             highest  pixel  count of a certain label in the corresponding
             source region. If the region comprises two  labels  with  the
             same  count,  the  one with the lower number wins., supported
             parameters are:

                 out-size =(required, 2dbounds)
                   target size given as two coma separated values.

   load      Load the input image from a file and use it  to  replace  the
             current image in the pipeline., supported parameters are:

                 file =(input, required, string)
                   name of the input file to load from..

   mask      2D masking, one of the two input images must by of type bit.,
             supported parameters are:

                 fill = min; dict
                   fill style for pixels outside of the  mask.   Supported
                   values are:
                       max    set  values outside the mask to the maximum
                       value found in the image..
                       zero  set the values outside the mask to zero.
                       min  set values outside the mask  to  the  minimum
                       value found in the image.

                 input =(input, required, string)
                   second input image file name.

                 inverse = 0; bool
                   set to true to use the inverse of the mask for masking.

   maxflow   This   filter   implements  the  uses  the  max-flow  min-cut
             algorithmfor image segmentation, supported parameters are:

                 sink-flow =(input, required, string)
                   Image of float type to define the per-pixel flow to the
                   sink.

                 source-flow =(input, required, string)
                   Image of float type to define the per-pixel flow to the
                   source.

   mean      2D image mean filter, supported parameters are:

                 w = 1; int in [1, inf)
                   half filter width.

   meanvar   Filter that evaluates simultaniously the pixel wise mean  and
             the variance of an image in a given window. Pixel intensities
             below the given  threshold  will  be  ignored  and  at  their
             loctions  the  output mean and variation are set to zero. The
             mean intensity image is directly passed as float image to the
             pipeline,  the  variation image is saved to a file given with
             the varfile parameter., supported parameters are:

                 thresh = 0; double in [0, inf)
                   Intensity   thresholding   parameter:    Pixels    with
                   intensities  below  this threshold will be set to zero,
                   and also not used when evaluating mean and variation.

                 varfile =(output, required, string)
                   name of the output file to  save  the  variation  image
                   too..

                 w = 1; uint in [1, inf)
                   filter width parameter.

   median    2D image median filter, supported parameters are:

                 w = 1; int in [1, inf)
                   half filter width.

   medianmad Filter  that  evaluates  simultaniously the pixel wise median
             and the median absolute deviation (MAD)  of  an  image  in  a
             given  window.  Pixel  intensities  below the given threshold
             will be ignored and at their loctions the output  median  and
             MAD  are  set to zero. The median intensity image is directly
             passed to the pipeline, the variation image  is  saved  to  a
             file  given  with  the  varfile parameter. Both output images
             have the same pixel type like  the  input  image.,  supported
             parameters are:

                 madfile =(output, required, string)
                   name  of  the  output  file to save the median absolute
                   deviation image too..

                 thresh = 0; double in [0, inf)
                   Intensity   thresholding   parameter:    Pixels    with
                   intensities  below  this threshold will be set to zero,
                   and also not used when evaluating mean and variation.

                 w = 1; uint in [1, inf)
                   filter width parameter.

   mlv       Mean of Least Variance 2D image filter, supported  parameters
             are:

                 w = 1; int in [1, inf)
                   filter width parameter.

   ngfnorm   2D image to normalized-gradiend-field-norm filter

                 (no parameters)

   noise     2D  image noise filter: add additive or modulated noise to an
             image, supported parameters are:

                 g = [gauss:mu=0,sigma=10]; factory
                   noise   generator.    For   supported   plug-ins    see
                   PLUGINS:generator/noise

                 mod = 0; bool
                   additive or modulated noise.

   open      morphological open, supported parameters are:

                 hint = black; set
                   a  hint  at  the  main image content.  Supported values
                   are:( black,  white,  )

                 shape = [sphere:r=2]; factory
                   structuring  element.   For  supported   plug-ins   see
                   PLUGINS:2dimage/shape

   pruning   Morphological  pruning.  Pruning until convergence will erase
             all pixels but closed loops., supported parameters are:

                 iter = 0; int in [1, 1000000]
                   Number of iterations to run, 0=until convergence.

   regiongrow
             Region  growing  startin  from  a  seed  until   only   along
             increasing gradients, supported parameters are:

                 n = 8n; factory
                   Neighborhood   shape.    For   supported  plug-ins  see
                   PLUGINS:2dimage/shape

                 seed =(input, required, string)
                   seed image (bit valued).

   sandp     salt and pepper  3d filter, supported parameters are:

                 thresh = 100; float in (0, inf)
                   thresh value.

                 w = 1; int in [1, inf)
                   filter width parameter.

   scale     2D image downscale filter, supported parameters are:

                 interp = [bspline:d=3]; factory
                   interpolation method to be used .  For supported  plug-
                   ins see PLUGINS:1d/splinekernel

                 s = [[0,0]]; 2dbounds
                   target size as 2D vector.

                 sx = 0; uint in [0, inf)
                   target size in x direction, 0: use input size.

                 sy = 0; uint in [0, inf)
                   target size in y direction, 0: use input size.

   selectbig 2D label select biggest component filter

                 (no parameters)

   sepconv   2D  image  intensity  separaple convolution filter, supported
             parameters are:

                 kx = [gauss:w=1]; factory
                   filter kernel in x-direction.  For  supported  plug-ins
                   see PLUGINS:1d/spacialkernel

                 ky = [gauss:w=1]; factory
                   filter  kernel  in y-direction.  For supported plug-ins
                   see PLUGINS:1d/spacialkernel

   shmean    2D  image  filter  that  evaluates  the  mean  over  a  given
             neighborhood shape, supported parameters are:

                 shape = 8n; factory
                   neighborhood shape to evaluate the mean.  For supported
                   plug-ins see PLUGINS:2dimage/shape

   sobel     The 2D Sobel filter for gradient evaluation.  Note  that  the
             output  pixel  type  of the filtered image is the same as the
             input pixel type, so converting the  input  beforehand  to  a
             floating  point  valued  image  is  recommendable., supported
             parameters are:

                 dir = x; dict
                   Gradient direction.  Supported values are:
                       y  gradient in y-direction
                       x  gradient in x-direction

   sort-label
             This plug-in sorts the labels of a gray-scale image  so  that
             the  lowest label value corresponts to the lable with themost
             pixels. The background (0) is not touched

                 (no parameters)

   sws       seeded watershead. The algorithm  extracts  exactly  so  many
             reagions  as  initial  labels  are  given in the seed image.,
             supported parameters are:

                 grad = 0; bool
                   Interpret the input image as gradient. .

                 mark = 0; bool
                   Mark the segmented watersheds with a special gray scale
                   value.

                 n = [sphere:r=1]; factory
                   Neighborhood   for   watershead  region  growing.   For
                   supported plug-ins see PLUGINS:2dimage/shape

                 seed =(input, required, string)
                   seed input image containing the lables for the  initial
                   regions.

   tee       Save  the  input  image to a file and also pass it through to
             the next filter, supported parameters are:

                 file =(output, required, string)
                   name of the output file to save the image too..

   thinning  Morphological  thinning.  Thinning  until  convergence   will
             result in a 8-connected skeleton, supported parameters are:

                 iter = 0; int in [1, 1000000]
                   Number of iterations to run, 0=until convergence.

   thresh    This  filter  sets  all  pixels of an image to zero that fall
             below a certain threshold and whose  neighbours  in  a  given
             neighborhood   shape   also  fall  below  a  this  threshold,
             supported parameters are:

                 shape = 4n; factory
                   neighborhood shape to take into account.  For supported
                   plug-ins see PLUGINS:2dimage/shape

                 thresh = 5; double
                   The threshold value.

   tmean     2D  image thresholded tmean filter: The output pixel value is
             zero if the input pixel value is below the  given  threshold,
             otherwise  the  pixels  in  the  evaluation  windows are only
             considered  if  the  input  pixel  intensity  is  above   the
             threshold., supported parameters are:

                 t = 0; float
                   Threshold for pixels not to take into account.

                 w = 1; int in [1, inf)
                   half filter width.

   transform Transform  the  input  image  with the given transformation.,
             supported parameters are:

                 file =(input, required, string)
                   Name of the file containing the transformation..

   ws        basic watershead segmentation., supported parameters are:

                 evalgrad = 0; bool
                   Set to 1 if  the  input  image  does  not  represent  a
                   gradient norm image.

                 mark = 0; bool
                   Mark the segmented watersheds with a special gray scale
                   value.

                 n = [sphere:r=1]; factory
                   Neighborhood  for  watershead  region   growing.    For
                   supported plug-ins see PLUGINS:2dimage/shape

                 thresh = 0; float in [0, 1)
                   Relative  gradient  norm  threshold.  The  actual value
                   threshold value is thresh *  (max_grad  -  min_grad)  +
                   min_grad.  Bassins  separated by gradients with a lower
                   norm will be joined.

PLUGINS: 2dimage/io

   bmp       BMP  2D-image  input/output  support.  The  plug-in  supports
             reading  and  writing  of  binary images and 8-bit gray scale
             images. read-only support is provided for  4-bit  gray  scale
             images.  The  color table is ignored and the pixel values are
             taken as literal gray scale values.

                 Recognized file extensions:  .BMP, .bmp

                 Supported element types:
                   binary data, unsigned 8 bit

   datapool  Virtual IO to and from the internal data pool

                 Recognized file extensions:  .@

   dicom     2D image io for DICOM

                 Recognized file extensions:  .DCM, .dcm

                 Supported element types:
                   signed 16 bit, unsigned 16 bit

   exr       a 2dimage io plugin for OpenEXR images

                 Recognized file extensions:  .EXR, .exr

                 Supported element types:
                   unsigned 32 bit, floating point 32 bit

   jpg       a 2dimage io plugin for jpeg gray scale images

                 Recognized file extensions:  .JPEG, .JPG, .jpeg, .jpg

                 Supported element types:
                   unsigned 8 bit

   png       a 2dimage io plugin for png images

                 Recognized file extensions:  .PNG, .png

                 Supported element types:
                   binary data, unsigned 8 bit, unsigned 16 bit

   raw       RAW 2D-image output support

                 Recognized file extensions:  .RAW, .raw

                 Supported element types:
                   binary data, signed 8 bit, unsigned 8  bit,  signed  16
                   bit,  unsigned  16 bit, signed 32 bit, unsigned 32 bit,
                   floating point 32 bit, floating point 64 bit

   tif       TIFF 2D-image input/output support

                 Recognized file extensions:  .TIF, .TIFF, .tif, .tiff

                 Supported element types:
                   binary data, unsigned 8 bit, unsigned 16 bit,  unsigned
                   32 bit

   vista     a 2dimage io plugin for vista images

                 Recognized file extensions:  .-, .V, .VISTA, .v, .vista

                 Supported element types:
                   binary  data,  signed  8 bit, unsigned 8 bit, signed 16
                   bit, unsigned 16 bit, signed 32 bit, unsigned  32  bit,
                   floating point 32 bit, floating point 64 bit

PLUGINS: 2dimage/shape

   1n        A shape that only contains the central point

                 (no parameters)

   4n        4n neighborhood 2D shape

                 (no parameters)

   8n        8n neighborhood 2D shape

                 (no parameters)

   rectangle rectangle shape mask creator, supported parameters are:

                 fill = 1; bool
                   create a filled shape.

                 height = 2; int in [1, inf)
                   height of rectangle.

                 width = 2; int in [1, inf)
                   width of rectangle.

   sphere    Closed  spherical  neighborhood shape of radius r., supported
             parameters are:

                 r = 2; float in (0, inf)
                   sphere radius.

   square    square shape mask creator, supported parameters are:

                 fill = 1; bool
                   create a filled shape.

                 width = 2; int in [1, inf)
                   width of rectangle.

PLUGINS: 2dtransform/io

   bbs       Binary (non-portable) serialized IO of 2D transformations

                 Recognized file extensions:  .bbs

   datapool  Virtual IO to and from the internal data pool

                 Recognized file extensions:  .@

   vista     Vista storage of 2D transformations

                 Recognized file extensions:  .v2dt

   xml       XML serialized IO of 2D transformations

                 Recognized file extensions:  .x2dt

PLUGINS: generator/noise

   gauss     This  noise  generator  creates  random   values   that   are
             distributed according to a Gaussien distribution by using the
             Box-Muller transformation., supported parameters are:

                 mu = 0; float
                   mean of distribution.

                 seed = 0; uint in [0, inf)
                   set random seed (0=init based on system time).

                 sigma = 1; float in (0, inf)
                   standard derivation of distribution.

   uniform   Uniform noise generator  using  C  stdlib  rand(),  supported
             parameters are:

                 a = 0; float
                   lower bound if noise range.

                 b = 1; float
                   higher bound if noise range.

                 seed = 0; uint in [0, inf)
                   set random seed (0=init based on system time).

EXAMPLE

   Evaluate the MAD-image of the bounding box surrounding the segmentation
   from a series segment.set after applying a temporal Gaussian filter  of
   width 5. No spacial filtering will be applied. The bounding box will be
   enlarged by 3 pixels in all directions.  Store  the  image  in  OpenEXR
   format.

   mia-2dseriessmoothgradMAD -i segment.set -o mad.exr -g 2 -c -e 3

AUTHOR(s)

   Gert Wollny

COPYRIGHT

   This  software  is Copyright (c) 19992015 Leipzig, Germany and Madrid,
   Spain.   It  comes   with   ABSOLUTELY   NO  WARRANTY   and   you   may
   redistribute  it  under  the  terms  of  the GNU GENERAL PUBLIC LICENSE
   Version 3 (or later). For more information run  the  program  with  the
   option '--copyright'.





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